If you’re among the millions struggling with dry, gritty, or burning eyes, a new FDA-approved treatment offers hope. TRYPTYR® (acoltremon ophthalmic solution) 0.003% is breaking ground in dry eye management. Let’s break down what makes it unique and how it could help you.
What is TRYPTYR?
TRYPTYR is a prescription eye drop approved in 2025 for treating the signs and symptoms of dry eye disease. Its active ingredient, acoltremon, works differently than artificial tears or anti-inflammatory drops. Instead, it targets your eyes’ natural tear-production system.
How Does It Work?
TRYPTYR activates TRPM8 thermoreceptors – cold-sensing proteins on your eye’s surface. This triggers your trigeminal nerve to ramp up basal tear production. Simply put: it tells your eyes to make more real tears, addressing dryness at its source.
Key Benefits of TRYPTYR Backed by Science
Two major studies (COMET-2 and COMET-3) proved TRYPTYR’s effectiveness:
- 42–53% of patients saw tear production increase by ≥10 mm after just 14 days.
- Results were 3–4× better than placebo and lasted through 90 days of use.
How to Use Tryptyr Ophthalmic Solution?
- Dosage: 1 drop in each eye, twice daily (morning and night, 12 hours apart).
- Vial Type: Single-use preservative-free vials (no risk of contamination).
- Critical Steps:
- Wash hands first.
- Don’t touch the vial tip to your eye or any surface.
- Remove contacts before applying – wait 15 mins to reinsert.
- If using other eye drops, space them 5+ minutes apart.
Possible Side Effects
The most common issue is temporary eye pain at application (reported by 50% in trials). Less than 1% stopped treatment due to stinging.
Special Considerations
- Pregnancy/Lactation:
- Low systemic absorption, but consult your doctor.
- Children:
- Not studied in under-18s.
- Seniors:
- Safe for older adults.
Storage & Handling
- Unopened: Refrigerate (36–46°F / 2–8°C).
- Opened: Can store at room temp (36–77°F / 2–25°C) for up to 30 days.
- After opening foil pouch: Use vials within 7 days.
Patient Tips from the Label
- One vial = both eyes. Discard immediately after use.
- If you miss a dose: Skip it – don’t double up. Resume at the next scheduled time.
- Never reuse vials – contamination risk is high.
The Bottom Line
TRYPTYR isn’t just another lubricant. By boosting your natural tears, it targets the *cause* of dry eye. While application-site discomfort may occur, its efficacy in restoring tear flow is clinically proven.
Always consult your ophthalmologist to see if TRYPTYR fits your dry eye plan. Never self-prescribe. For full safety details, review the FDA label
Sources & Disclaimers
- Based on TRYPTYR Prescribing Information (Alcon, 2025).
- This blog provides general info only. Not medical advice. Consult your healthcare provider.
