Gallium Dotatate Ga-68 is a radiolabeled agent that is used during PET scanning for the localization of somatostatin receptor-positive neuroendocrine tumors.
Gallium Ga-68 DOTATATE Uses:
-
Diagnostic imaging:
- Gallium Ga-68 DOTATATE is Used with positron emission tomography (PET) after radiolabeling with Ga 68 for localization of somatostatin receptor-positive neuroendocrine tumors (NETs) in adult and pediatric patients.
Gallium Dotatate Dose in Adults
Gallium Dotatate Dose in the Diagnostic imaging:
- IV: 2 MBq/kg (0.054 mCi/ per kg).
- The maximum dose can be 200 MBq (5.4 mCi).
- After completion of gallium Ga 68 dotatate administration begin PET scanning forty to ninety minutes later.
Gallium Dotatate Dose in Childrens
Gallium Dotatate Dose in Diagnostic imaging:
- IV: 2 MBq/kg (0.054 mCi/kg).
- The maximum dose is 200 MBq per dose.
- After the completion of gallium Ga 68 dotatate administration begin PET scanning forty to ninety minutes later.
Pregnancy Category: N
- It has not been used in animal reproduction studies.
Use during breastfeeding:
- It is unknown if breastmilk contains gallium ga 68.
- Following the administration of the drug, the manufacturer suggests that breastfeeding be stopped for 12 hours.
- After that time, it is recommended to discard breastmilk.
Dose in Kidney Disease:
- There are no dosage adjustments provided in the manufacturer's labeling.
Dose in Liver disease:
- There are no dosage adjustments provided in the manufacturer's labeling.
Side effects of Gallium Dotatate:
Allergic reactions manifesting as:
- itching,
- hives
- urticaria
- cough
- shortness of breath
- hypotension
- shock
- nausea
- vomiting
Contraindications to Gallium Dotatate Ga-68:
The manufacturer's labeling does not contain any contraindications.
Warnings and precautions
-
Radiation accumulation:
- Based on long-term cumulative radiation exposure, Ga 68 could accumulate.
- Long-term cumulative radiation exposure is linked to the risk of developing cancer.
- Radiation exposure should not be allowed to patients or health care professionals.
Monitoring Parameters:
None mentioned.
How to administer Gallium Dotatate Ga-68?
- It is administered intravenously as an IV bolus.
- Immediately before the administration, measure and verify the radioactivity in the syringe with a dose calibrator to ensure radioactivity administered is within 10% of the recommended dose.
- Imaging should include whole-body acquisition from the skull to mid-thigh.
- Begin PET scanning 40 to 90 minutes after its administration.
- Patients should ensure hydration by drinking a sufficient amount of water before the administration of the radiopharmaceutical agent and in the first hours following administration and void frequently following administration to reduce the exposure to radiation.
- It should be handled and disposed-off with appropriate precautions. Radiation should be minimized when handling it by following appropriate safety measures during handling and administering it.
- Effective shielding (including syringe shielding) and waterproof gloves should be worn by the person who handles and administer it.
Mechanism of action of Gallium Dotatate Ga-68:
- It's a radioactive diagnostic agent.
- It binds to cells with somatostatin receptors, including malignant cells.
- Gallium 68 (Ga) is a beta+-emitting radionuclide that emits radiation with an emission yield that permits positron emission imaging (PET).
- Imaging will not allow you to visualize tumors that lack somatostatin receptors.
Distribution:
- It is widely distributed to all somatostatin 2 (sstr2)-expressing organisms including the pituitary, thyroid, adrenal, spleen and liver.
Half-life elimination:
- It can be decomposed in 68 minutes with stable zinc ZN68.
Excretion:
- It is excreted in the urine (12% within the first four hours).
International Brand Names of Gallium Ga-68 DOTATATE:
- Netspot
- Galliapharm
- GalliaPharm
Gallium Ga-68 DOTATATE Brand Names in Pakistan:
No Brands Available in Pakistan.
