Ozenoxacin Cream (Xepi) is a quinolone antibiotic that is used as a topical cream for the treatment of impetigo in children and adults.

Ozenoxacin Cream Uses:

• Impetigo:

  • It is approved for the treatment of adult and paediatric patients 2 months of age and older with impetigo brought on by Staphylococcus aureus or Streptococcus pyogenes.

Ozenoxacin Cream (Xepi) Dose in Adults

Ozenoxacin Cream (Xepi) Dose in the treatment of Impetigo:

• Two times daily for five days, it is topically administered in a thin layer to the afflicted area.
• There should be no more than 100 cm2 in total.

Ozenoxacin Cream (Xepi) Dose in Children

Dosage of oznoxacin cream (Xepi) for impetigo in children older than 2 months:

• For five days, the affected area receives two applications of a thin coating each time.
• Note: For patients under the age of 12, the total afflicted area may be up to 2% of the total BSA, but it should not exceed 100 cm2.

Pregnancy Category: N (not assigned)

• Topical application is not a means of exposing fetal to systemic or systemic radiation.

Use during breastfeeding:

• It is unknown if the drug will be excreted into breast milk. The drug cannot be absorbed topically so it is unlikely that the drug will get into breastmilk.
• It is recommended that pregnant women use it with caution, considering the possible risks to the baby and the benefits for the mother.

Dose in Kidney Disease:

There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment is unlikely due to low systemic absorption.

Dose in Liver Disease:

The manufacturer's labelling does not mention dosage modifications. However, due to limited systemic absorption, dosage modification is improbable.

Side effects of Ozenoxacin Cream (Xepi):

• Skin itching
• Dryness
• peeling of the skin
• redness
• flaking of the skin

Contraindications to Ozenoxacin Cream (Xepi):

The manufacturer's labeling does not list any contraindications. Patients with allergies to any ingredient or medicine should stay away, according to Canadian labelling.

Warnings and precautions

• Superinfection

  • Long-term use can result in superinfections with bacteria and fungi that may not cure. If superinfections develop, the treatment should be stopped immediately.

Monitoring Parameters:

Monitor the response to treatment.

How to administer Ozenoxacin Cream (Xepi)?

• It is intended for topical use only.
• Oral, intranasal, rectal, ophthalmic, or intravaginal use should be avoided.
• The impacted area is covered with a thin covering.
• A sterile bandage or a gauze dressing may be used to cover the treated region.
• After application, hands should be washed with soap water.

Mechanism of action of Ozenoxacin Cream (Xepi):

It is part of the quinolone antibiotic class that acts by inhibiting DNA replication enzymes in bacteria, topoisomerase I, and DNA gyrase B.

Absorption:

• It cannot be absorbed through the skin.

International Brand Names of Ozenoxacin Cream:

• Xepi
• Ozadub
• Ozanex
• Zebiax

Ozenoxacin Brand Names in Pakistan:

No Brands Available in Pakistan.