Dextrose 25% and sodium chloride 10% are both types of intravenous (IV) solutions commonly used in medical settings. These solutions are often prescribed by healthcare professionals for various clinical purposes. Here's a brief explanation of each solution:
- Dextrose 25%:
- Dextrose is another term for glucose, which is a type of sugar.
- Dextrose 25% is a concentrated solution that contains 25 grams of glucose in 100 milliliters of solution.
- It is typically used to provide a source of energy and nourishment to the body, especially for patients who require a rapid increase in blood sugar levels or for those who are unable to consume food orally.
- It is also used in emergency situations to treat hypoglycemia (low blood sugar) and as a vehicle for administering other medications.
- Sodium Chloride 10%:
- Sodium chloride is commonly referred to as salt and is an essential electrolyte in the body.
- Sodium chloride 10% is a hypertonic saline solution that contains 10 grams of sodium chloride (salt) in 100 milliliters of solution.
- It is primarily used for specific medical conditions where a hypertonic saline solution is required. These situations may include the treatment of certain types of severe dehydration, hyponatremia (low blood sodium levels), and other medical conditions.
Sclerodex contains 25% dextrose and 10% sodium chloride. It is used as a sclerosing agent for the treatment of varicose veins of the smaller veins and their communicating branches.
Dextrose 25% and sodium chloride 10% Uses:
- Sclerosing agent:
- It is a mild sclerosing agent and is used as a local treatment of varicose veins as an adjunct to surgery.
- It is especially recommended for smaller vessels and communicating veins of the superficial venous system.
Sclerodex (Dextrose 25% and sodium chloride 10%) Dose in Adults
Sclerodex Dose as a Sclerosing agent:
- Use it through an intravenous (IV) injection.
- The amount you use (dose) should be between 0.1 and 1 milliliter (mL).
- The specific amount depends on how long and big the vein you are treating is.
- Don't use more than a total of 10 mL in one visit or treatment session.
Sclerosing agents are typically used to close or treat veins for medical purposes, like varicose vein treatment.
Use in Children:
Not indicated.
Preganancy Risk Category: C
- Its use during pregnancy and breastfeeding is not known.
- It is best to delay elective procedures, such as the treatment for varicose veins, until after the birth.
- The gravid uterus can cause varicosity in the veins of lower limbs to worsen during pregnancy.
Dose in Kidney Disease:
There are no dosage adjustments provided in the manufacturer’s labeling.
Dose in Liver disease:
There are no dosage adjustments provided in the manufacturer’s labeling.
Side effects of Sclerodex:
- There are no adverse reactions listed in the manufacturer's labeling.
- Observe for allergic reactions and thrombosis of the veins.
- Pulmonary embolism may occur.
- Patients may develop features of fluid overload especially in the background of impaired cardiac and renal functions.
Contraindication to Sclerodex (Dextrose 25% and sodium chloride 10%):
- Recent superficial or deep thrombophlebitis (6 months to 2 years):
- If you've had blood clots in your veins (superficial or deep) in the past 6 months to 2 years, you should be careful or avoid certain treatments.
- Varicose veins caused by abdominal or pelvic tumors:
- If your varicose veins are a result of tumors in your abdomen or pelvis, it's important to consider this when planning treatment.
- Potential underlying arterial disease:
- If there's a possibility that you have problems with your arteries, this needs to be taken into account.
- Renal or cardiac insufficiencies accompanied by venous stasis or dilatation:
- If you have kidney or heart problems along with issues like slowed blood flow or vein widening, special care is needed.
- Angina pectoris:
- If you have chest pain (angina pectoris), this is a concern and should be considered during medical procedures.
- Local or systemic infections:
- If you have an infection in a specific area or throughout your body, it's important to be cautious.
- Hyperthyroidism:
- If you have an overactive thyroid (hyperthyroidism), it's a condition that needs special attention.
- Uncontrolled diabetes mellitus:
- If your diabetes is not properly managed and controlled, it's a factor to be aware of during medical decisions.
Warnings and precautions
Hypersensitivity
- Be aware that people can have different levels of allergic reactions, from mild to very serious.
- Keep an eye out for any signs of allergies or sensitivity when using this treatment.
Thromboembolism
- Be careful when using this treatment in people with a history of blood clots (DVT) or those at higher risk for blood clots, like those taking birth control pills.
- Blood clots might travel to the lungs and cause a pulmonary embolism.
- Don't use this treatment in people who had superficial or deep blood clots in the past 6 months to 2 years, as it's not recommended in these cases.
Monitoring Parameters:
None mentioned.
How to administer Sclerodex (Dextrose 25% and sodium chloride 10%)?
- This medicine should only be given through an intravenous (IV) route.
- It's important to prevent it from leaking outside of the vein or being injected into an artery, as this can harm the nearby tissues and cause tissue death (ischemia and necrosis).
- When injecting in different spots, make sure to leave about 2 inches (around 5 centimeters) of space between the injection sites to avoid complications.
Mechanism of action of Sclerodex:
- It is a chemical irritation that causes endothelial injury by direct caustic destruction.
- Fibrosis of the vessel endothelium results from the inflammatory process.
- It is a weak agent that can be used to treat varicose veins in the smaller blood vessels.
International Brands of Dextrose 25% and sodium chloride 10%:
- Sclerodex
Dextrose 25% and sodium chloride 10% Brand Names in Pakistan:
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Glucose Injection 5 %W/V in Pakistan |
|
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Dextrose With Normal Sline |
Marions Laboratories Pakistan |
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Dextrose With Normal Sline |
Marions Laboratories Pakistan |
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Macsol Ds |
Searle Pakistan (Pvt.) Ltd. |
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Macsol Ds |
Searle Pakistan (Pvt.) Ltd. |
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Sterifluid |
Frontier Dextrose Ltd |
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Sterifluid |
Frontier Dextrose Ltd |
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Sterifluid |
Frontier Dextrose Ltd |
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Glucose Injection 4.3 %W/V in Pakistan |
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Dextrose 4.3%+0.9% Nacl |
Lahore Chemical & Pharmaceutical Works (Pvt) Ltd |
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Macsol Ds 1/2 |
Searle Pakistan (Pvt.) Ltd. |
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Macsol Paeds |
Mac & Rans Pharmaceuticals (Pvt) Ltd |
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Sterifluid Peads |
Frontier Dextrose Ltd |
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Glucose Injection 8.25 %W/V in Pakistan |
|
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Bupicain Sp |
Lahore Chemical & Pharmaceutical Works (Pvt) Ltd |
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Glucose Infusion 5 G/L in Pakistan |
|
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Plabolyte-40 |
Otsuka Pakistan Ltd. |
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Ringolact-D |
Otsuka Pakistan Ltd. |
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Ringolact-D |
Otsuka Pakistan Ltd. |
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Solvein Ringars D |
Siza International (Pvt) Ltd. |
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Solvein Ringars D |
Siza International (Pvt) Ltd. |
|
Sterilyte-M |
Frontier Dextrose Ltd |
|
Glucose Infusion 5 %W/V in Pakistan |
|
|
Dextrose 10%+0.9% Nacl |
Elko Organization (Pvt) Ltd. |
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Dextrose 10%+0.9% Nacl |
Elko Organization (Pvt) Ltd. |
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Dextrose 5% + Nacl 0.45 % |
Atlantic Pharmaceuticals (Pvt) Ltd. |
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Dextrose 5%+0.45% Nacl |
Elko Organization (Pvt) Ltd. |
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Dextrose 5%+0.45% Nacl |
Elko Organization (Pvt) Ltd. |
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Dextrose 5%+0.45% Nacl |
Geofman Pharmaceuticals |
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Dextrose 5%+0.9 % Nacl |
Lahore Chemical & Pharmaceutical Works (Pvt) Ltd |
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Dextrose 5%+0.9 % Nacl |
Lahore Chemical & Pharmaceutical Works (Pvt) Ltd |
|
Dextrose 5%+0.9% Nacl |
Elko Organization (Pvt) Ltd. |
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Dextrose 5%+0.9% Nacl |
Elko Organization (Pvt) Ltd. |
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Dextrose 5%+Nacl 0.9 % |
Atlantic Pharmaceuticals (Pvt) Ltd. |
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Immunasol Dn |
A.Z. Pharmaceuticals Co. |
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Immunasol Dn |
A.Z. Pharmaceuticals Co. |
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Lifesol 5%+Nacl 0.9% |
Geofman Pharmaceuticals |
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Lifesol 5%+Nacl 0.9% |
Geofman Pharmaceuticals |
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Medisol 1/2 Strength |
Medipak Limited |
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Medisol-S |
Medipak Limited |
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Medisol-S |
Medipak Limited |
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Plabolyte-M |
Otsuka Pakistan Ltd. |
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Plabolyte-M |
Otsuka Pakistan Ltd. |
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Pladexsal |
Otsuka Pakistan Ltd. |
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Pladexsal |
Otsuka Pakistan Ltd. |
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Pladexsal 1/2 |
Otsuka Pakistan Ltd. |
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Plasmax -70 |
Otsuka Pakistan Ltd. |
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Zeesol-Ds |
Shahzaib Pharmaceuticals (Pvt) Ltd. |
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Zeesol-Ds |
Shahzaib Pharmaceuticals (Pvt) Ltd. |
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Glucose Infusion 10 %W/V in Pakistan |
|
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Dextrose 10%+0.45% Nacl |
Elko Organization (Pvt) Ltd. |
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Dextrose 10%+0.45% Nacl |
Elko Organization (Pvt) Ltd. |
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Dextrose 10%+0.9% Nacl |
Geofman Pharmaceuticals |
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Glucose Infusion 3.3 %W/V in Pakistan |
|
|
Dextrose 3.3%+0.3% Nacl |
Elko Organization (Pvt) Ltd. |
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Dextrose 3.3%+0.3% Nacl |
Geofman Pharmaceuticals |
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Medisol N/3 |
Medipak Limited |
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Pladexsal 1/3 |
Otsuka Pakistan Ltd. |
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Glucose Infusion 4.3 %W/V in Pakistan |
|
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Dextrose 4.3%+0.18% Nacl |
Elko Organization (Pvt) Ltd. |
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Dextrose 4.3%+0.9% Nacl |
Elko Organization (Pvt) Ltd. |
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Medisol Peads |
Medipak Limited |
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Pladexsal 1/5 |
Otsuka Pakistan Ltd. |
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Searl Peads |
Searle Pakistan (Pvt.) Ltd. |
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Glucose Infusion 135 G/1000ml in Pakistan |
|
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Nutriflex® |
Usmanco International |
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Glucose Infusion 150 G/1000ml in Pakistan |
|
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Nutriflex Plus |
B. Braun Pakistan (Pvt) Ltd. |
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Nutriflex Plus |
B. Braun Pakistan (Pvt) Ltd. |
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Glucose Infusion 240 G/1000ml in Pakistan |
|
|
Nutrifllex Special |
B. Braun Pakistan (Pvt) Ltd. |
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Nutrifllex Special |
B. Braun Pakistan (Pvt) Ltd. |
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Glucose Infusion 112.5 G/1000ml in Pakistan |
|
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Nutriflex Lipid |
B. Braun Pakistan (Pvt) Ltd. |
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Glucose Syrup 3.96 Mg/5ml in Pakistan |
|
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Multina Plus |
Helicon Pharmaceutek Pakistan (Pvt) Ltd. |
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New Molton-S |
Epoch Pharmaceutical |
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New Molton-S |
Epoch Pharmaceutical |
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Veena Forte |
Medicraft Pharmaceuticals (Pvt) Ltd. |
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Glucose Solution 15 G/L in Pakistan |
|
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Hypertonic Solution |
Siza International (Pvt) Ltd. |
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Solvein Iso |
Siza International (Pvt) Ltd. |
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Glucose Solution 17 G/L in Pakistan |
|
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Peritoneal Dialysis Soln. |
Medipak Limited |
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Glucose Solution 20 G/L in Pakistan |
|
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Paedicare Apple |
W.Woodward Pakistan (Pvt) Ltd. |
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Glucose Solution 1.5 G/L in Pakistan |
|
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Peritoneal Dialysis Soln With Dextrose |
Elko Organization (Pvt) Ltd. |
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Glucose Solution 1.5 %W/V in Pakistan |
|
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Peri Solution |
Otsuka Pakistan Ltd. |
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Glucose Solution 4.25 G/L in Pakistan |
|
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Peritoneal Dialysis Soln With Dextrose |
Elko Organization (Pvt) Ltd. |
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Glucose Solution 10 G/500ml in Pakistan |
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Sterilyte |
Frontier Dextrose Ltd |
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Glucose Solution 10 Mg/500ml in Pakistan |
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Pedialife Solution |
Sapient Pharma |
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Glucose Oral Solution 10 G/500ml in Pakistan |
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Babilyte |
Medipak Limited |
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Lecklyte |
Medimarkers Pharmaceuticals |
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Medelate |
Mediate Pharmaceuticals (Pvt) Ltd |
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Neolyte |
Neo Medix |
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Neolyte |
Neo Medix |
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Nysol |
Raazee Theraputics (Pvt) Ltd. |
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Oem |
Indus Pharma (Pvt) Ltd. |
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Paedicare (Ice Cream Soda) |
W.Woodward Pakistan (Pvt) Ltd. |
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Pedia Fresh |
Fozan Pharmaceuticals Industriers (Pvt) Ltd |
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Pedinex |
Nexus Pharma (Pvt) Ltd |
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Peditral Banana |
Searle Pakistan (Pvt.) Ltd. |
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Peditral Bubble Gum |
Searle Pakistan (Pvt.) Ltd. |
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Peditral Orange |
Searle Pakistan (Pvt.) Ltd. |
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Peditral Regular |
Searle Pakistan (Pvt.) Ltd. |
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Pedscure |
Jawa Pharmaceuticals(Pvt) Ltd. |
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Glucose Liquid 10 G/500ml in Pakistan |
|
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Pedialyte |
Abbott Laboratories (Pakistan) Limited. |
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Pedialyte Apple |
Abbott Laboratories (Pakistan) Limited. |
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Pedialyte Bubble Gum |
Abbott Laboratories (Pakistan) Limited. |
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Glucose Sachet 20 G in Pakistan |
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Anglo |
Euro Pharma International |
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Arosal F |
Alliance Pharmaceuticals (Pvt) Ltd. |
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Baby-S |
Saydon Pharmaceutical Industries (Pvt) Ltd. |
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Benmosol |
Benson Pharamceuticals. |
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Davisalts |
Davis Pharmaceutical Laboratories |
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Davisalts |
Davis Pharmaceutical Laboratories |
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Dirosal |
Bloom Pharmaceuticals (Pvt) Ltd. |
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Geofman Sp |
Geofman Pharmaceuticals |
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Geofman Sp |
Geofman Pharmaceuticals |
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Glucolyte |
Global Pharmaceuticals |
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Hydrosol |
Star Laboratories (Pvt) Ltd. |
|
Hydrosol |
Star Laboratories (Pvt) Ltd. |
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Kemytral |
Alkemy Pharmaceutical Laboratories (Private) Ltd. |
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Neolyte-Ors |
Pharmedic (Pvt) Ltd. |
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Novosal |
Krka-Pak Pharmaceutical & Chemical Works |
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Oem |
Indus Pharma (Pvt) Ltd. |
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Orabest |
Pearl Pharmaceuticals |
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Oralyte |
Karachi Chemical Industries |
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Orasal-F |
Wilsons Pharmaceuticals |
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Orazaf |
Zafa Pharmaceutical Laboratories (Pvt) Ltd. |
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Orsigen |
Genera Pharmaceuticals |
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Osal |
Paramount Pharmaceuticals |
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Osal |
Paramount Pharmaceuticals |
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Osal |
Paramount Pharmaceuticals |
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Paeditol |
Pharmawise Labs. (Pvt) Ltd. |
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Paeditrex |
Helicon Pharmaceutek Pakistan (Pvt) Ltd. |
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Paeditrex |
Helicon Pharmaceutek Pakistan (Pvt) Ltd. |
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Pedilina |
Alina Combine Pharmaceuticals (Pvt) Ltd. |
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Peditral |
Searle Pakistan (Pvt.) Ltd. |
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Pehydrate |
Pharmawise Labs. (Pvt) Ltd. |
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Pexolyte O.R.S. |
Karachi Pharmaceutical Laboratory |
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Resal |
Cirin Pharmaceuticals (Pvt) Ltd. |
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Scots O.R.S |
Scotmann Pharmaceuticals |
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Sure-Ors |
Medisure Laboratories Pakistan (Pvt.) Ltd. |
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Synitral |
Syntex Pharmaceuticals |
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Teknosol |
Hygeia Pharmaceuticals |
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Valosal |
Valor Pharmaceuticals |
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Werisol |
Werrick Pharmaceuticals |
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Glucose Sachet 13.5 G in Pakistan |
|
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Ferolytel |
Ferozsons Laboratoies Ltd. |
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Glusol |
Warafana Pharmaceuticals |
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Orsal |
Well & Well Pharma (Pvt) Ltd |
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Glucose Sachet 3.56 G/5.177g in Pakistan |
|
|
Diarolyte Orange |
Sanofi Aventis (Pakistan) Ltd. |
