Technetium 99m mebrofenin is a radio-diagnostic imaging product used for the diagnosis of hepatobiliary disorders. At the recommended dosage, it does not possess any pharmacokinetic activities.
Technetium Tc-99m mebrofenin Uses:
-
Imaging agent:
- Hepatobiliary imaging agent
Technetium 99m Dose in Adults
Technetium 99m Dose in the treatment of Hepatobiliary imaging:
- IV (based on 70 kg patient): 2 to 5 mCi (74 to 185 MBq)
Technetium 99m Dose in Childrens
Not mentioned.
Pregnancy Risk Factor CIt is insoluble and opaque to xrays.
- Studies on animal reproduction have not been done.
- Technetium Tc99m can be detected within fetal tissue. The amount depends on the formulation, route of administration and the duration of the pregnancy.
- The likelihood of fetal side effects from radiopharmaceuticals depends on how much the drug is absorbed and how long the pregnancy has been.
- Radiopharmaceuticals that are used in therapeutic procedures at high doses are more likely than to cause harm to fetal health.
- Modifying a medically necessary diagnostic procedure to reduce fetal risk is possible.
- It is best to delay elective diagnostic procedures until after delivery.
- Women with childbearing potential should determine their pregnancy status.
Tc-99m mebrofenin use during breastfeeding:
- Breast milk contains Technetium Tc99m.
- Manufacturer recommends using formula instead of breast-feeding formula.
- Technetium Tc99m mebrofenin information has not yet been found.
- However, one source suggests that breastfeeding should be stopped immediately after technetium 99m compounds are administered for 12 hours.
- Women with a stable milk supply should continue to breastfeed after the administration of radiopharmaceuticals.
- The amount of technetium Tc99m excreted into colostrum can vary widely and information is scarce.
- Therefore, it is difficult to make recommendations regarding early breast-feeding (Mountford 1989; Rubow 1994).
- It is important to delay elective diagnostic procedures until after breastfeeding has stopped.
- It may be necessary to comply with all regulatory requirements regarding recordkeeping and instructions to patients, depending on the dose.
Tc-99m Dose in Kidney Disease:
No dosage adjustment provided in the manufacturer’s labeling.
Tc-99m Dose in Liver disease:
Serum bilirubin >1.5 mg/dL: 3 to 10 mCi (111 to 370 MBq)
Side effects of Technetium 99m:
-
Dermatologic:
- Skin rash
- Urticaria
Contraindications to Tc-99m mebrofenin:
Hypersensitivity to Tc99m mebrofenin, or any other component of the formulation
Warnings and precautions
-
Hypersensitivity reactions
- Patients who receive multiple doses of medication may experience allergic reactions.
-
Meperidine or morphine sulfate use:
- Recent use of imaging agents may slow down intestinal transit, resulting in non-visualization.
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Hepatic impairment
- Possible causes of delayed visualization or non-visualization.
Monitor:
Infusion reactions
How to administer Technetium Tc-99m mebrofenin?
IV:
- For IV administration.
- The test should be performed while the patient is fasting; avoid interference with opioids by delaying the study for 4 hours after the last dose.
- Radiopharmaceutical; use appropriate precautions for handling and disposal.
Mechanism of action of Tc-99m mebrofenin:
It is a radioactive diagnostic agent which decays by the isomeric transition to emit a photon that can be detected by imaging
It provides radiographic studies with a positive contrast.
The onset of action:
- Detectable in the hepatic duct and gallbladder within 10 to 15 minutes and in the intestinal tract within 30 to 60 minutes
Half-life elimination:
- 6.02 hours
Excretion:
- Urine (1% within 3 hours; 3% within 3 hours in patients with elevated serum bilirubin)
International Brands of Technetium Tc-99m mebrofenin:
- Bridatec
- Cholecis
- Cholediam
- Hibida
Technetium Tc-99m mebrofenin Brand Names in Pakistan:
No Brands Available in Pakistan.
